|
 Back to Partner Search Theme List
Partner Search Form
| CODE |
HEALTH-IT-01BPN-1 |
| TITLE |
Genes-Environment Interaction on Respiratory Diseases (GEIRD) |
| PROGRAMME / THEME |
Health |
| FUNDING SCHEME |
Best Practice Networks (BPN) |
| DEADLINE |
21/11/2008 |
| ORGANISATION TYPE |
University |
| PROJECT DESCRIPTION |
4.3 Specific International Cooperation Actions (SICA)
4.3.3-1: Comparative population genetic studies on multifactorial diseases
The role of genetic and environmental factors, as well as of their interaction, in the natural history of asthma, allergic rhinitis and obstructive pulmonary disease (COPD), is largely unknown. This is mainly due to the lack of large scale, analytical epidemiological/genetic studies aimed at investigating the three respiratory conditions simultaneously.
GEIRD is a multicenter study aimed at clarifying and quantifying the role that oxidative stress, diet and genes (and their interactions) play in the occurrence, persistence and severity of asthma, rhinitis and COPD. The three respiratory diseases will be studied simultaneously by means of a nested multi case-control design, where cases and controls are identified from the general population through a two-stage screening process (questionnaire + clinical stage), both in pre-existing cohorts and in a new probability sample. Phenotypes (cases) of asthma, rhinitis and COPD and controls will be accurately defined in the clinical stage, where eligible subjects will undergo lung function testing, skin prick tests, exhaled nitric oxide (FENO), exhaled breath condensate, urine collection for 8-hydroxy-2'-deoxyguanosine (8-OHdG) measurement, a standardized clinical interview and blood samples for genetic analysis.
Cases and controls giving their consent will be administered a nutritional food frequency questionnaire (EPIC questionnaire) by trained personnel during a visit at home. Individual (ozone, formaldehyde) and environmental contaminant exposure will be also measured.
In this way, an open, freely accessible, multi-centre cases and controls database will be created. Research teams will contribute to increase the database of cases and controls and the survey will consequently exploit the enlarged resulting study power to answer the stated scientific questions.
DURATION: 3 years |
| PARTNER SOUGHT |
Type of partners they are looking for and their expected roles in the project:
- Epidemiologists, pneumologists, environmental experts, genetists of academic, research or clinic centres |
|
|
